The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …

Acute appendicitis (AA) is a common abdominal emergency with a lifetime prevalence of
about 7%. As the clinical diagnosis of AA remains a challenge to emergency physicians and …

Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI …

Neglected tropical diseases (NTDs) are communicable diseases that occur under conditions
of poverty and are concentrated almost exclusively in impoverished populations in the …

Background Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans
infection that damages the skin and subcutis. It is most prevalent in western and central …

Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in
southeastern Australia and spreading into new geographic areas. We analyzed 426 cases …

The first description of chronic skin ulcers consistent with the pathology of Mycobacterium
ulcerans infection dates back to the end of the nineteenth century, when the British physician …

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the
etiological agent of Buruli ulcer. Its involvement in lesion development has been widely …

Buruli ulcer (BU) is a neglected tropical skin disease caused by Mycobacterium ulcerans.
Infection foci occur mainly in remote, rural areas of Central and West Africa, but also in …