Anticancer compounds based on isatin-derivatives: Strategies to ameliorate selectivity and efficiency

RE Ferraz de Paiva, EG Vieira… - Frontiers in molecular …, 2021 - frontiersin.org
In this review we compare and discuss results of compounds already reported as anticancer
agents based on isatin-derivatives, metalated as well as non-metallated. Isatin compounds …

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

XG Bai, Y Zheng, J Qi - Frontiers in Pharmacology, 2022 - frontiersin.org
The great success of cisplatin as a chemotherapeutic agent considerably increased
research efforts in inorganic biochemistry to identify more metallic drugs having the potential …

Synthesis of palladium (II) complexes via Michael addition: antiproliferative effects through ROS-mediated mitochondrial apoptosis and docking with SARS-CoV-2

J Haribabu, S Srividya, D Mahendiran… - Inorganic …, 2020 - ACS Publications
Metal complexes have numerous applications in the current era, particularly in the field of
pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a …

Coordination compounds of pyrazolone‐based ligand: Design, characterization, biological evaluation, antitumor efficiency, and DNA binding evaluation supported by …

SA Ibrahim, A Ragab… - Applied Organometallic …, 2022 - Wiley Online Library
Abstract Cu (II), Ni (II), Mn (II), and Cr (III) chelates of the organic ligand named 3‐(furan‐2‐
yl)‐5‐oxo‐N, 1‐diphenyl‐4, 5‐dihydro‐1H‐pyrazole‐4‐carbothioamide ligand (abbreviated …

A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)

S Chowdhary, Shalini, A Arora, V Kumar - Pharmaceuticals, 2022 - mdpi.com
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …

Metal Complexes in cancer treatment: Journey so far

A Kumar Singh, A Kumar, H Singh… - Chemistry & …, 2023 - Wiley Online Library
Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

Effect of N-benzyl group in indole scaffold of thiosemicarbazones on the biological activity of their Pd (II) complexes: DFT, biomolecular interactions, in silico docking …

N Balakrishnan, J Haribabu, RE Malekshah… - Inorganica Chimica …, 2022 - Elsevier
A series of N-benzyl substituted indole-based thiosemicarbazone (TSC) ligands (L4-L6) and
palladium (II) TSC complexes,[Pd (L) 2](1–6)(L= monoanionic bidentate un/N-substituted …

Influence of Indole-N Substitution of Thiosemicarbazones in Cationic Ru(II)(η6-Benzene) Complexes on Their Anticancer Activity

N Balakrishnan, J Haribabu, M Dharmasivam… - …, 2023 - ACS Publications
Indole thiosemicarbazones (TSCs) and their complexes are known to possess various
biological activities. The variation in anticancer activity with different indole-N substituents of …

N-substitution in isatin thiosemicarbazones decides nuclearity of Cu (II) complexes–Spectroscopic, molecular docking and cytotoxic studies

J Haribabu, OI Alajrawy, K Jeyalakshmi… - … Acta Part A: Molecular …, 2021 - Elsevier
Abstract The mono-(1) and bi-nuclear (2) copper (II) complexes containing N-substituted
isatin thiosemicarbazone (s) were synthesized, and characterized by analytical and …

Water-soluble mono-and binuclear Ru (η6-p-cymene) complexes containing indole thiosemicarbazones: synthesis, DFT modeling, biomolecular interactions, and in …

J Haribabu, G Sabapathi, MM Tamizh… - …, 2018 - ACS Publications
Indole thiosemicarbazone ligands were prepared from indole-3-carboxaldehyde and N-(un)
substituted thiosemicarbazide. The Ru (η6-p-cymene) complexes [Ru (η6-p-cymene)(HL1) …