CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Mass spectrometry has transformed the field of cell signaling by enabling global studies of
dynamic protein phosphorylation ('phosphoproteomics'). Recent developments are enabling …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that
convey communication from adipose tissue to other organs. Here, to delineate their role as …

Cytochrome c (Cytc) 1 is a cellular life and death decision molecule that regulates cellular
energy supply and apoptosis through tissue specific post-translational modifications. Cytc is …

Proteomics experiments commonly aim to estimate and detect differential abundance across
all expressed proteins. Within this experimental design, some of the most challenging …

The architecture of cristae provides a spatial mitochondrial organization that contains
functional respiratory complexes. Several protein components including OPA1 and MICOS …

Diabetes is a global public health burden and is characterized clinically by relative or
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …

Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth
and metabolism that senses and integrates nutritional and environmental cues with cellular …