The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Xanthine and its derivatives are considered an important class of N-heterocyclic purine
compounds that have gained significant importance in medicinal chemistry. N-heterocyclic …

Covalent drugs emerged as a promising addition to the arsenal of medicinal chemistry tools.
Here, a gold-templated mechanism is exploited to enable the selective covalent targeting of …

The use of three-dimensional self-assembled metallacages (MCgs) as multimodal drug
platforms holds great promise. However, the synthesis of MCgs with increased complexity …

While platinum (II)-based drugs continue to be employed in cancer treatments, the
escalating occurrence of severe side effects has spurred researchers to explore novel …

Herein, we report the structure-based selection via molecular docking of four N-heterocyclic
bis-carbene gold (I) complexes, whose potential as ligands for the hTel23 G-quadruplex …

Cyclometalated gold (III) complexes have been reported to template CS cross-coupling
reactions in a biological environment and acting as modifiers of cysteine residues. To …

The use of three-dimensional self-assembled metallacages (MCgs) as theranostic platforms
holds great promise. This work reports on the integration of a gold (III) porphyrin scaffold into …

The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (G4C2) …

This thesis work is structured into four main sections. The first chapter is a general
introduction, initiated with a discussion of the structure and the electronic properties of N …