Oncogenic effects of HIV-1 proteins, mechanisms behind

M Isaguliants, E Bayurova, D Avdoshina… - Cancers, 2021 - mdpi.com
Simple Summary People living with human immunodeficiency virus type 1 (HIV-1)(PLWH)
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …

A tale of two viruses: immunological insights into HCV/HIV coinfection

ST Gobran, P Ancuta, NH Shoukry - Frontiers in immunology, 2021 - frontiersin.org
Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …

Chinese guidelines for the diagnosis and treatment of HIV/AIDS (2021 edition)

AIDS and Hepatitis C Professional Group … - Infectious Diseases & …, 2022 - mednexus.org
Acquired immunodeficiency syndrome (AIDS) is an important public health problem in
China. In 2005, the first edition of the guidelines for the diagnosis and treatment of AIDS was …

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

Q Xiao, L Yan, J Han, S Yang, Y Tang, Q Li, X Lao… - …, 2022 - thelancet.com
Background HIV immune non-responders (INRs) are described as a failure to reestablish a
pool of CD4+ T lymphocytes (CD4 cells) after antiretroviral therapy (ART), which is related to …

Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

J Richard, J Prévost, C Bourassa, N Brassard… - Cell chemical …, 2023 - cell.com
Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …

[PDF][PDF] Failure of CD4+ T-cell recovery upon virally-effective cART: an enduring gap in the understanding of HIV+ immunological non-responders

V Bono, M Augello, C Tincati, G Marchetti - New Microbiol, 2022 - newmicrobiologica.org
A unique definition of INR is currently unavailable. Over the years, INRs have generally
been described as subjects who did not reach pre-defined CD4+ lymphocyte counts (ie 200 …

Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection

LY Wan, HH Huang, C Zhen, SY Chen… - Emerging Microbes & …, 2023 - Taylor & Francis
Chronic inflammation and T cell dysregulation persist in individuals infected with human
immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The …

Comparing immune responses to inactivated vaccines against SARS-CoV-2 between people living with HIV and HIV-negative individuals: a cross-sectional study in …

X Huang, Y Yan, B Su, D Xiao, M Yu, X Jin, J Duan… - Viruses, 2022 - mdpi.com
This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between
people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and …

Thymic exhaustion and increased immune activation are the main mechanisms involved in impaired immunological recovery of HIV-positive patients under ART

MC Dos Santos Guedes, WHV Carvalho-Silva… - Viruses, 2023 - mdpi.com
Decades of studies in antiretroviral therapy (ART) have passed, and the mechanisms that
determine impaired immunological recovery in HIV-positive patients receiving ART have not …

Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV

S Espineira, M Flores-Piñas, S Chafino… - Frontiers in …, 2023 - frontiersin.org
Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual
recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related …