The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines
mechanical strength with efficient barrier function. In this paper, we discuss these …

Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer [EOS])
are essential components of the lipid skin barrier, which protects our body from excessive …

Nanoparticles have become versatile assets in the medical field, providing notable benefits
across diverse medical arenas including controlled drug delivery, imaging, and …

This review is summarizing an important part of the state of the art in stratum corneum
research. A complete overview on discoveries about the general biophysical and …

The increased interest of the scientific community in lipid nanoparticles has pushed the
boundaries of personal medicine and drug delivery. The focus has been set on vesicular …

Lipid membrane remodeling belongs to the most fundamental processes in the body. The
skin barrier lipids, which are ceramide dominant and highly rigid, must attain an unusual …

The lipid phase of the uppermost human skin layer is thought to comprise highly rigid lipids
in an orthorhombic phase state to protect the body against the environment. By synthesizing …

The ester-linked ω-hydroxy acyl chain linked to a sphingosine base referred to as CER EOS
is essential for the skin barrier lipid organization. While the majority of the skin lipids form a …