Neonatal chronic lung disease, also known as bronchopulmonary dysplasia (BPD), is the
most common complication of premature birth, affecting up to 30% of very low birth weight …

Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV)
represents one of the most challenging scenarios for aerosol medicine. This challenge is …

The reason why some infants with respiratory distress syndrome fail to respond to surfactant,
or respond only transiently, is incompletely understood. We hypothesized that resuscitation …

Integrating basic and clinical research on the biophysical and physiological functions of
pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on …

With a randomized clinical trial, the possibility was assessed that a tracheal instillation of
pulmonary surfactant prior to the first breath might prevent the development of some of the …

We performed a randomized, prospective clinical trial comparing intratracheal administration
of human surfactant with conventional treatment with intermittent mandatory mechanical …

We have previously reported the development of a reconstituted lung surfactant consisting of
an organic solvent extract of natural bovine lung surfactant supplemented with synthetic …

Bovine pulmonary surfactant was obtained by endotracheal lavage of lungs from newly
slaughtered cows followed by differential centrifugation. Lipid extracts of bovine surfactant …

With a pulsating bubble surfactometer we assessed the ability of various agents, fibrinogen,
human serum, albumin, and a 55,000-dalton serum protein, to interfere with the surface …

Extracted bovine calf lung lipids (CLL) with minimal protein (approximately 1%) were
instilled prior to ventilation in groups of premature lambs of average gestational ages of 127 …