Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator …
Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti- tumour immunity in solid tumours. In patients with advanced prostate cancer …
Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2 infection,, but the host response at the lung tissue level is poorly understood. Here we …
Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages within the context of heterogeneous tissues. However, current single-cell data cannot …
Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
AB Keenan, D Torre, A Lachmann… - Nucleic acids …, 2019 - academic.oup.com
Identifying the transcription factors (TFs) responsible for observed changes in gene expression is an important step in understanding gene regulatory networks. ChIP-X …
J Biermann, JC Melms, AD Amin, Y Wang, LA Caprio… - Cell, 2022 - cell.com
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
R Aggarwal, J Huang, JJ Alumkal, L Zhang… - Journal of Clinical …, 2018 - ascopubs.org
Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor …
Prostate cancers are considered to be immunologically 'cold'tumors given the very few patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …