The DREAM complex: master coordinator of cell cycle-dependent gene expression
S Sadasivam, JA DeCaprio - Nature Reviews Cancer, 2013 - nature.com
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
The recurrent architecture of tumour initiation, progression and drug sensitivity
A Califano, MJ Alvarez - Nature Reviews Cancer, 2017 - nature.com
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …
architecture in which genomic alterations cluster upstream of functional master regulator …
Androgen receptor activity in T cells limits checkpoint blockade efficacy
Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti-
tumour immunity in solid tumours. In patients with advanced prostate cancer …
tumour immunity in solid tumours. In patients with advanced prostate cancer …
A molecular single-cell lung atlas of lethal COVID-19
Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection,, but the host response at the lung tissue level is poorly understood. Here we …
infection,, but the host response at the lung tissue level is poorly understood. Here we …
Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages
within the context of heterogeneous tissues. However, current single-cell data cannot …
within the context of heterogeneous tissues. However, current single-cell data cannot …
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
ChEA3: transcription factor enrichment analysis by orthogonal omics integration
AB Keenan, D Torre, A Lachmann… - Nucleic acids …, 2019 - academic.oup.com
Identifying the transcription factors (TFs) responsible for observed changes in gene
expression is an important step in understanding gene regulatory networks. ChIP-X …
expression is an important step in understanding gene regulatory networks. ChIP-X …
[HTML][HTML] Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
J Biermann, JC Melms, AD Amin, Y Wang, LA Caprio… - Cell, 2022 - cell.com
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: a multi-institutional prospective study
Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine
prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor …
prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor …
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …