During the last 40 years, there has been a world-wide increase in both the prevalence of
obesity and an increase in the number of persons over the age of 60 due to a decline in …

Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex
organs. Despite this, the global landscape of intercellular signaling in mammalian liver has …

Background & Aims The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly
understood, with males and certain populations exhibiting markedly increased susceptibility …

Various reports have suggested that secreted frizzled-related protein (SFRP) 5 (SFRP5)
plays a regulatory role in the processes of cellular proliferation and differentiation, by means …

In recent decades, the prevalence of obesity has risen dramatically worldwide among all
age groups. Obesity is characterized by excess fat accumulation and chronic low-grade …

Inflammation and oxidative stress are key steps in the progression of non‑alcoholic
steatohepatitis (NASH). Intervention in these two processes will therefore benefit NASH …

Non‐alcoholic steatohepatitis (NASH) is a devastating form of non‐alcoholic fatty liver
disease (NAFLD). Pyrvinium pamoate (PP) has been recently introduced as anti-adipogenic …

With the increasing prevalence of obesity, obesity-related problems such as cardiometabolic
disorders (CMD), are also rapidly increasing. To prevent and alleviate the progressive …

Metabolic diseases pose a significant global health challenge, characterized by an
imbalance in metabolism and resulting in various complications. Secreted frizzled-related …