The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

Abstract CRISPR/Cas9-based genome-editing therapies are poised to change the clinical
outcome for many diseases with validated therapeutic targets awaiting an appropriate …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

The presence of melanin pigment within the iris is responsible for the visual impression of
human eye colouration with complex patterns also evident in this tissue, including Fuchs' …

The strictly regulated expression of most pleiotropic developmental control genes is critically
dependent on the activity of long-range cis-regulatory elements. This was revealed by the …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

Glaucoma is the leading cause of irreversible blindness worldwide. Although most
glaucoma patients are elderly, congenital glaucoma and glaucomas of childhood are also …