Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …

Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Increasing evidence from animal and human studies suggests that inflammation may be
involved in mood disorders. Sickness behavior and emotional changes induced by …

Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Depression is one of the global leading causes of disability, but treatments remain limited
and classical antidepressants were found to be ineffective in a substantial proportion of …

Objective Currently, no valid measures inform treatment selection for depressed patients.
Whether C-reactive protein (CRP) in particular and two other acute phase reactants …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

A wealth of evidence has implicated inflammation in the development of depression. Yet, the
heterogeneous nature of depression has impeded efforts to understand, prevent, and treat …