Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

During the course of evolution, multicellular organisms have been orchestrated with an
efficient and versatile immune system to counteract diverse group of pathogenic organisms …

Commensal intestinal microbes are collectively beneficial in preventing local tissue injury
and augmenting systemic antimicrobial immunity. However, given the near-exclusive focus …

Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including
bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Patients with loss of function in the gene encoding the master regulator of central tolerance
AIRE suffer from a devastating disorder called autoimmune polyendocrine syndrome type 1 …

Over the last decade, invasive fungal infections have emerged as a growing threat to human
health worldwide and novel treatment strategies are urgently needed. In this context …

Mucocutaneous fungal infections are typically found in patients who have no known immune
defects. We describe a family in which four women who were affected by either recurrent …