Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …

The existing suite of therapies for bone diseases largely act to prevent further bone loss but
fail to stimulate healthy bone formation and repair. We describe an endogenous …

Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …

Dynamin superfamily proteins are multidomain mechano‐chemical GTPases which are
implicated in nucleotide‐dependent membrane remodeling events. A prominent feature of …

Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely
unexplored whether lysine acetylation regulates membrane protein function. Here, we use …

Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …

Copper plays a critical role in prion protein (PrP) physiology. Cu 2+ binds with high affinity to
the PrP N-terminal octarepeat (OR) domain, and intracellular copper promotes PrP …

Endocytic and recycling pathways generate cargo-laden transport carriers by membrane
fission. Classical dynamins, which generate transport carriers during endocytosis, constrict …

Caveolae are small Ω-shaped invaginations of the plasma membrane that play important
roles in mechanosensing, lipid homeostasis and signaling. Their typical morphology is …