Phosphoryl transfer is a fundamental reaction in cellular signaling and metabolism that
requires Mg2+ as an essential cofactor. While the primary function of Mg2+ is electrostatic …

Biological life depends on motion, and this manifests itself in proteins that display motion
over a formidable range of time scales spanning from femtoseconds vibrations of atoms at …

Enzymes employ a wide range of protein motions to achieve efficient catalysis of chemical
reactions. While the role of collective protein motions in substrate binding, product release …

This study explores ligand-driven conformational changes in adenylate kinase (AK), which is
known for its open-to-close conformational transitions upon ligand binding and release. By …

Enzymatic catalysis is critically dependent on selectivity, active site architecture, and
dynamics. To contribute insights into the interplay of these properties, we established an …

Enzymatic substrate selectivity is critical for the precise control of metabolic pathways. In
cases where chemically related substrates are present inside cells, robust mechanisms of …

Escherichia coli adenylate kinase (AdK) is a small, monomeric enzyme that synchronizes
the catalytic step with the enzyme's conformational dynamics to optimize a phosphoryl …

The sea cucumber Apostichopus japonicus (Selenka) is a valuable economic species in
Southeast Asia. It has many fascinating behavioral characteristics, such as autolysis …

Evolutionarily conserved polo-like kinase, Cdc5 (Plk1 in humans), associates with
kinetochores during mitosis; however, the role of cell cycle–dependent centromeric (CEN) …

As a key molecule in biology, adenosine triphosphate (ATP) has numerous crucial functions
in, for instance, energetics, post-translational modifications, nucleotide biosynthesis, and …