Remodeling in asthma and chronic obstructive lung disease
PK Jeffery - American journal of respiratory and critical care …, 2001 - atsjournals.org
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of
the lung associated with structural “remodeling” inappropriate to the maintenance of normal …
the lung associated with structural “remodeling” inappropriate to the maintenance of normal …
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
Airway structural alterations selectively associated with severe asthma
L Benayoun, A Druilhe, MC Dombret… - American journal of …, 2003 - atsjournals.org
To identify airway pathologic abnormalities selectively associated with severe asthma, we
examined 10 control subjects, 10 patients with intermittent asthma, 15 patients with mild-to …
examined 10 control subjects, 10 patients with intermittent asthma, 15 patients with mild-to …
Airway gland structure and function
JH Widdicombe, JJ Wine - Physiological reviews, 2015 - journals.physiology.org
Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
[HTML][HTML] Paucigranulocytic asthma: uncoupling of airway obstruction from inflammation
O Tliba, RA Panettieri Jr - Journal of Allergy and Clinical Immunology, 2019 - Elsevier
Among patients with asthma, heterogeneity exists regarding the pattern of airway
inflammation and response to treatment, prompting the necessity of recognizing specific …
inflammation and response to treatment, prompting the necessity of recognizing specific …
Airway smooth muscle cell proliferation is increased in asthma
PRA Johnson, M Roth, M Tamm, M Hughes… - American journal of …, 2001 - atsjournals.org
Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has
been well documented and is likely to be the result of increased muscle proliferation. We …
been well documented and is likely to be the result of increased muscle proliferation. We …
Airway smooth muscle in the pathophysiology and treatment of asthma
DC Doeing, J Solway - Journal of applied physiology, 2013 - journals.physiology.org
Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …
responsible for acute bronchoconstriction, which is potentiated by constrictor …
TGF-β activation and lung fibrosis
Lung fibrosis can affect the parenchyma and the airways, classically giving rise to idiopathic
pulmonary fibrosis (IPF) in the parenchyma or airway remodeling in asthma and chronic …
pulmonary fibrosis (IPF) in the parenchyma or airway remodeling in asthma and chronic …
Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation
To quantify the number of goblet cells and inflammatory cells in the epithelium of peripheral
airways in smokers with both symptoms of chronic bronchitis and chronic airflow limitation …
airways in smokers with both symptoms of chronic bronchitis and chronic airflow limitation …