The effectiveness of somatic cell nuclear transfer (SCNT) in mammals seems to be still
characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny …

Techniques for genetic engineering of swine have been directed toward avoiding naturally
existing cellular and antibody responses to species-specific antigens. Organs from …

Oropeza M, Petersen B, Carnwath JW, Lucas‐Hahn A, Lemme E, Hassel P, Herrmann D,
Barg‐Kues B, Holler S, Queisser A‐L, Schwinzer R, Hinkel R, Kupatt C, Niemann H …

Adipose tissue was only recently considered as a potential source of mesenchymal stem
cells (MSCs) for bone tissue engineering. To improve the osteogenicity of acellular bone …

Abstract Development of a transgenic porcine biomedical research model requires effective
delivery of DNA into the donor cell followed by selection of genetically modified somatic cell …

For more than a century, transplantation of tissues and organs from animals into man,
xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest …

Pigs are increasingly being recognized as good large-animal models for translational
research, linking basic science to clinical applications in order to establish novel …

Leigh syndrome (LS) associated with cytochrome c oxidase (COX) deficiency is an early
onset, fatal mitochondrial encephalopathy, leading to multiple neurological failure and …

Contents Somatic cell nuclear transfer (SCNT) was first developed in livestock for the
purpose of accelerating the widespread use of superior genotypes. Although many …

Pluripotent cells, such as embryonic stem (ES) cells, embryonic germ cells and embryonic
carcinoma cells are a unique type of cell because they remain undifferentiated indefinitely in …