Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

Histone post-transcriptional modifications play essential roles in regulation of all DNA
related processes. Among them, histone ubiquitination has been discovered for more than …

Traditional anticancer chemotherapeutics targeting DNA replication and cell division have
severe side effects, but they have proved to be highly successful in treating some cancers …

Biological roles for UFM1, a ubiquitin-like protein, are largely unknown, and therefore we
screened for targets of ufmylation. Here we show that ufmylation of the nuclear receptor …

Hypoxia-inducible transcription factors (HIFs) are fundamental to cellular adaptation to low
oxygen levels, but it is unclear how they interact with chromatin and activate their target …

Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …

The estrogen receptor α (ERα) controls cell proliferation and tumorigenesis by recruiting
various cofactors to estrogen response elements (EREs) to control gene transcription. A …