The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Abstract p53 protects mammals from neoplasia by inducing apoptosis, DNA repair and cell
cycle arrest in response to a variety of stresses. p53-dependent arrest of cells in the G1 …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle.
Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were …

The E2F transcription factor family determines whether or not a cell will divide by controlling
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct …

Smad3 is a direct mediator of transcriptional activation by the TGFβ receptor. Its target genes
in epithelial cells include cyclin-dependent kinase inhibitors that generate a cytostatic …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …

Most cervical carcinomas express high-risk human papillomaviruses (HPVs) E6 and E7
proteins, which neutralize cellular tumor suppressor function. To determine the …

The E2F transcription factor plays a pivotal role in the timely activation of gene expression
during mammalian cell cycle progression, whereas pRB and related proteins control cell …

The retinoblastoma tumor suppressor protein (pRB) is a transcriptional repressor that
regulates gene expression by physically associating with transcription factors such as E2F …