Hyperpolarized 129Xe MRI at low field: Current status and future directions

S Perron, A Ouriadov - Journal of Magnetic Resonance, 2023 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) is dictated by the magnetization of the sample,
and is thus a low-sensitivity imaging method. Inhalation of hyperpolarized (HP) noble gases …

3He diffusion MRI in human lungs

JC Woods, MS Conradi - Journal of Magnetic Resonance, 2018 - Elsevier
Hyperpolarized 3 He gas allows the air spaces of the lungs to be imaged via MRI. Imaging of
restricted diffusion is addressed here, which allows the microstructure of the lung to be …

Comparison of in vivo lung morphometry models from 3D multiple b‐value 3He and 129Xe diffusion‐weighted MRI

HF Chan, GJ Collier, ND Weatherley… - Magnetic Resonance in …, 2019 - Wiley Online Library
Purpose To compare in vivo lung morphometry parameters derived from theoretical gas
diffusion models, the cylinder model and stretched exponential model, in a range of acinar …

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

A Westcott, F Guo, G Parraga… - Journal of Magnetic …, 2019 - Wiley Online Library
Background Multi‐b diffusion‐weighted hyperpolarized‐gas MRI measures pulmonary
airspace‐enlargement using apparent diffusion coefficients (ADCs) and mean‐linear …

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

M Zhang, H Li, H Li, X Zhao, Q Zhou… - Magnetic …, 2020 - Wiley Online Library
Purpose To demonstrate the feasibility of 129Xe MR in evaluating the pulmonary
physiological changes caused by PM2. 5 in animal models. Methods Six rats were treated …

Accelerated 129Xe MRI morphometry of terminal airspace enlargement: Feasibility in volunteers and those with alpha‐1 antitrypsin deficiency

A Ouriadov, F Guo, DG McCormack… - Magnetic Resonance …, 2020 - Wiley Online Library
Purpose Multi‐b diffusion‐weighted hyperpolarized inhaled‐gas MRI provides imaging
biomarkers of terminal airspace enlargement including ADC and mean linear intercept (Lm) …

Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung

AV Ouriadov, MS Fox, AA Lindenmaier, E Stirrat… - … Resonance Materials in …, 2021 - Springer
Abstract Objective Diffusion-weighted, hyperpolarized 129 Xe MRI is useful for the
characterization of microstructural changes in the lung. A stretched exponential model was …

Undersampled Diffusion-Weighted 129Xe MRI Morphometry of Airspace Enlargement: Feasibility in Chronic Obstructive Pulmonary Disease

S Perron, DG McCormack, G Parraga, A Ouriadov - Diagnostics, 2023 - mdpi.com
Multi-b diffusion-weighted hyperpolarized gas MRI measures pulmonary airspace
enlargement using apparent diffusion coefficients (ADC) and mean linear intercepts (L m) …

Feasibility of Dynamic Inhaled Gas MRI-Based Measurements Using Acceleration Combined with the Stretched Exponential Model

R Sembhi, T Ranota, M Fox, M Couch, T Li, I Ball… - Diagnostics, 2023 - mdpi.com
Dynamic inhaled gas (3He/129Xe/19F) MRI permits the acquisition of regional fractional-
ventilation which is useful for detecting gas-trapping in lung-diseases such as lung fibrosis …

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications

A Westcott, DG McCormack, G Parraga… - Journal of Magnetic …, 2019 - Wiley Online Library
There are serious clinical gaps in our understanding of chronic lung disease that require
novel, sensitive, and noninvasive in vivo measurements of the lung parenchyma to measure …