Glucocorticoid for hearing preservation after cochlear implantation: a systemic review and meta-analysis of animal studies

C Shaul, PK Venkatagiri, J Lo, HT Eastwood… - Otology & …, 2019 - journals.lww.com
Objectives: To conduct systematic review and meta-analyses of preclinical studies
describing the efficacy of glucocorticoids administered via different routes for hearing …

The impact of electrode array length on hearing preservation in cochlear implantation

MC Suhling, O Majdani, R Salcher… - Otology & …, 2016 - journals.lww.com
Objective: The aim of the study was to determine the degree of hearing preservation (HP)
and its relation to electrode array length after cochlear implantation using different thin …

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

Y Hu, L Fang, H Zhang, S Zheng, M Liao, Q Cui… - Smart …, 2023 - Wiley Online Library
Hearing impairment is a global health problem that affects social communications and the
economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) …

High-precision 3D printing of microporous cochlear implants for personalized local drug delivery

A Isaakidou, I Apachitei, LE Fratila-Apachitei… - Journal of Functional …, 2023 - mdpi.com
Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global
population. Current treatments using the systemic administration of drugs are therapeutically …

A 3D microscaffold cochlear electrode array for steroid elution

J Jang, J Kim, YC Kim, S Kim, N Chou… - Advanced …, 2019 - Wiley Online Library
In cochlear implants, the electrode insertion trauma during surgery can cause damage
residual hearing. Preserving the residual hearing is an important challenge and the …

Long-term effects and potential limits of intratympanic dexamethasone-loaded hydrogels combined with dexamethasone-eluting cochlear electrodes in a low-insertion …

N Ahmadi, JC Gausterer, C Honeder, M Moetz… - Hearing Research, 2019 - Elsevier
Cochlear implantation has become the most effective hearing restoration method and is one
of the great advances in modern medicine. Early implants have been continuously …

Sialyllactose preserves residual hearing after cochlear implantation

MY Lee, SK Jung, J Jang, H Choi, YH Choung… - Scientific Reports, 2024 - nature.com
In individuals with hearing loss, protection of residual hearing is essential following cochlear
implantation to facilitate acoustic and electric hearing. Hearing preservation requires slow …

The effect of systemic steroid on hearing preservation after cochlear implantation via round window approach: a guinea pig model

MY Chang, YC Rah, JJ Choi, SW Woo… - Otology & …, 2017 - journals.lww.com
Background: The benefits of electroacoustic stimulation have led to interest in
pharmacological interventions to preserve hearing after CI. Methods: Thirty guinea pigs …

Dexamethasone delivery for hearing preservation in animal cochlear implant model: continuity, long-term release, and fast release rate

MY Lee, YC Kim, J Jang, JY Jung, H Choi… - Acta Oto …, 2020 - Taylor & Francis
Background: Clinically, steroids have been used for hearing preservation both topically and
systemically during cochlear implantation. Objective: This study compared steroid efficacy …

Microtechnologies for inner ear drug delivery

F Forouzandeh, DA Borkholder - Current opinion in …, 2020 - journals.lww.com
Microtechnologies for inner ear drug delivery : Current Opinion in Otolaryngology & Head and
Neck Surgery Microtechnologies for inner ear drug delivery : Current Opinion in Otolaryngology …