[HTML][HTML] The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease

S Cao, JL Fachi, K Ma, AU Antonova, Q Wang… - The Journal of Clinical …, 2024 - jci.org
Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is
linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and …

[HTML][HTML] Regulation of intestinal immunity by dietary fatty acids

J Qiu, Y Ma, J Qiu - Mucosal Immunology, 2022 - Elsevier
Dietary fatty acids are absorbed through the intestine and are fundamental for cellular
energy provision and structural formation. Dietary fatty acids profoundly affect intestinal …

Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity

Y Guo, Y Liu, B Rui, Z Lei, X Ning, Y Liu… - Frontiers in …, 2023 - frontiersin.org
The human gastrointestinal mucosa is colonized by thousands of microorganisms, which
participate in a variety of physiological functions. Intestinal dysbiosis is closely associated …

[HTML][HTML] Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3

R Tachó-Piñot, CT Stamper, JI King, V Matei-Rascu… - Cell reports, 2023 - cell.com
Innate lymphoid cells (ILCs) are tissue-resident effector cells with roles in tissue
homeostasis, protective immunity, and inflammatory disease. Group 3 ILCs (ILC3s) are …

Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

Y Li, J Ge, X Zhao, M Xu, M Gou, B Xie… - Journal of Experimental …, 2023 - rupress.org
Innate lymphoid cells (ILC) are similar to T helper (Th) cells in expression of cytokines and
transcription factors. For example, RORγt is the lineage-specific transcription factor for both …

Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3

JL Fachi, LP Pral, HC Assis, S Oliveira… - Gut …, 2024 - Taylor & Francis
Hyperbaric oxygen (HBO) therapy is a well-established method for improving tissue
oxygenation and is typically used for the treatment of various inflammatory conditions …

[HTML][HTML] Bcl-2 supports survival and metabolic fitness of quiescent tissue-resident ILC3

JI King, F Melo-Gonzalez, B Malengier-Devlies… - Mucosal …, 2023 - Elsevier
Group 3 innate lymphoid cells (ILC3) are potent effector cells with critical roles in enforcing
immunity, barrier integrity and tissue homeostasis along the gastrointestinal tract. ILC3 are …

ILC3: a case of conflicted identity

I Koprivica, S Stanisavljević, D Mićanović… - Frontiers in …, 2023 - frontiersin.org
Innate lymphoid cells type 3 (ILC3s) are the first line sentinels at the mucous tissues, where
they contribute to the homeostatic immune response in a major way. Also, they have been …

[HTML][HTML] There's no place like home: How local tissue microenvironments shape the function of innate lymphoid cells

LB Roberts, AM Kelly, MR Hepworth - Mucosal Immunology, 2025 - Elsevier
Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in
orchestrating the wider immune response. While ILC are relatively rare cells they are found …

Innate lymphoid cells and inflammatory bowel disease

V Peng, N Jaeger, M Colonna - Innate Lymphoid Cells, 2022 - Springer
The signature hallmark of adaptive immunity is the evolution of somatically rearranged
antigen receptors, which confer both diversity and specificity to T and B lymphocytes. For …