Genetic landscape and biomarkers of hepatocellular carcinoma

J Zucman-Rossi, A Villanueva, JC Nault, JM Llovet - Gastroenterology, 2015 - Elsevier
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Molecular classification of hepatocellular adenoma in clinical practice

JC Nault, V Paradis, D Cherqui, V Vilgrain… - Journal of …, 2017 - Elsevier
Hepatocellular adenomas (HCA) are rare benign liver tumors occurring in young women
taking contraception. They are associated with rare complications such as bleeding or …

Effect of Helicobacter pylori eradication on gastric cancer prevention: updated report from a randomized controlled trial with 26.5 years of follow-up

L Yan, Y Chen, F Chen, T Tao, Z Hu, J Wang, J You… - Gastroenterology, 2022 - Elsevier
Background & Aims Helicobacter pylori infection is considered as the most important risk
factor in the pathogenesis of gastric cancer. This study aims to evaluate the long-term effects …

HNF1A: From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus

LM Li, BG Jiang, LL Sun - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes, a disease characterized by hyperglycemia, has a serious impact on the lives and
families of patients as well as on society. Diabetes is a group of highly heterogeneous …

Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application

X Sun, W Yu, C Hu - BioMed research international, 2014 - Wiley Online Library
With rapidly increasing prevalence, diabetes has become one of the major causes of
mortality worldwide. According to the latest studies, genetic information makes substantial …

17q12 deletion syndrome as a rare cause for diabetes mellitus type MODY5

N Roehlen, H Hilger, F Stock, B Gläser… - The Journal of …, 2018 - academic.oup.com
Context Maturity-onset diabetes of the young type 5 (MODY5) is caused by mutations of the
hepatocyte nuclear factor 1 homeobox β gene (HNF1B). Although clinical characteristics …

Integrated analysis revealing a novel stemness-metabolism-related gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma

Y Wang, X Wan, S Du - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a malignant lethal tumor and both cancer stem cells
(CSCs) and metabolism reprogramming have been proven to play indispensable roles in …

[HTML][HTML] Serrated polyps of the colon and rectum: Remove or not?

W Sano, D Hirata, A Teramoto, M Iwatate… - World journal of …, 2020 - ncbi.nlm.nih.gov
In recent years, the serrated neoplasia pathway where serrated polyps arise as a colorectal
cancer has gained considerable attention as a new carcinogenic pathway. Colorectal …

[HTML][HTML] Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

J Putra, LD Ferrell, ASH Gouw, V Paradis, A Rishi… - Modern Pathology, 2020 - Elsevier
The molecular classification of hepatocellular adenomas highlights a distinctive genotype-
phenotype correlation. Malignant transformation is an exceptionally rare complication of …

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

P Sneha, R Siva, H Zayed - PLoS One, 2017 - journals.plos.org
Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes
associated with poor insulin secretion. Over the past years, several studies have reported …