The human CMV (HCMV) genome consists of an approximately 230-kb dsDNA and is
predicted to contain over 165 open reading frames. Although the entire sequence of the …

Viral RNA genomes are modified by epitranscriptomic marks, including 2′-O-methylation
that is added by cellular or viral methyltransferases. 2′-O-Methylation modulates RNA …

Several physiologically relevant cations including Ca 2+, Mn 2+, and Zn 2+ have been
shown to inhibit HIV reverse transcriptase (RT), presumably by competitively displacing one …

The development of a modified DNA aptamer that binds HIV‐1 reverse transcriptase (RT)
with ultra‐high affinity has enabled the X‐ray structure determination of an HIV‐1 RT‐DNA …

Abstract HIV-1 reverse transcriptase (RT) slides over an RNA/DNA or dsDNA substrate while
copying the viral RNA to a proviral DNA. We report a crystal structure of RT/dsDNA complex …

DNA–RNA hybrids are heterogeneous nucleic acid duplexes consisting of a DNA strand
and a RNA strand, and are formed as key intermediates in many important biological …

DNA: RNA hybrid duplex plays important roles in various biological processes. Both its
structural stability and interactions with proteins are highly sequence dependent. In this …

A or B: RNA–DNA hybrids, key intermediates in gene regulation, were classified by pulsed
electron–electron double resonance (PELDOR) in combination with CD spectroscopy into …

The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer
DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding …

Although many new assays for HIV have been developed, several labs still use simple and
reliable radioactivity-based reverse transcriptase (RT) nucleotide incorporation assays for …