Pathogen recognition and inflammatory signaling in innate immune defenses

TH Mogensen - Clinical microbiology reviews, 2009 - Am Soc Microbiol
The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Therapeutic potential of Toll-like receptor 9 activation

AM Krieg - Nature reviews Drug discovery, 2006 - nature.com
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

J Scheiermann, DM Klinman - Vaccine, 2014 - Elsevier
Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …

Immunotherapeutic uses of CpG oligodeoxynucleotides

DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …

Pharmacological modulation of nucleic acid sensors—therapeutic potential and persisting obstacles

C Vanpouille-Box, JA Hoffmann… - Nature reviews Drug …, 2019 - nature.com
Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

M OhAinle, L Helms, J Vermeire, F Roesch, D Humes… - Elife, 2018 - elifesciences.org
Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively
identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of …

CpG oligonucleotides as vaccine adjuvants

N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides specifically
designed to stimulate Toll-like receptor 9. TLR9 is expressed on human plasmacytoid …

Mammalian Toll-like receptors: to immunity and beyond

PA Hopkins, S Sriskandan - Clinical & Experimental …, 2005 - academic.oup.com
Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their
sophisticated biology underpins the ability of innate immunity to discriminate between highly …

CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults

CL Cooper, HL Davis, JB Angel, ML Morris, SM Elfer… - Aids, 2005 - journals.lww.com
Background: HIV patients are vaccine hyporesponsive. Methods: We evaluated CPG 7909,
a synthetic oligodeoxynucleotide containing immunostimulatory CpG motifs, as an adjuvant …

The use of toll-like receptor agonists in HIV-1 cure strategies

JT Martinsen, JD Gunst, JF Højen, M Tolstrup… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first
line of defense against invading microbes. In humans, we know of 10 different TLRs, which …