Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

L Tuchscherr, B Löffler, RA Proctor - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus is able to survive within host cells by switching its phenotype to the
small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the …

MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation

S Dyzenhaus, MJ Sullivan, B Alburquerque, D Boff… - Cell host & …, 2023 - cell.com
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …

Biofilm and Small Colony Variants—An Update on Staphylococcus aureus Strategies toward Drug Resistance

H Guo, Y Tong, J Cheng, Z Abbas, Z Li, J Wang… - International journal of …, 2022 - mdpi.com
Recently, the drawbacks arising from the overuse of antibiotics have drawn growing public
attention. Among them, drug-resistance (DR) and even multidrug-resistance (MDR) pose …

Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

JB Parsons, AC Westgeest, BP Conlon, VG Fowler Jr - Antibiotics, 2023 - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible
for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its …

Diverse molecular mechanisms underpinning Staphylococcus aureus small colony variants

M Mapar, T Rydzak, JW Hommes, BGJ Surewaard… - Trends in …, 2024 - cell.com
Small colony variants (SCVs) of Staphylococcus aureus are a relatively rare but clinically
significant growth morphotype. Infections with SCVs are frequently difficult to treat, inherently …

[HTML][HTML] Staphylococcus aureus clones causing osteomyelitis: a literature review (2000–2020)

FP De Araujo, M Monaco, M Del Grosso… - Journal of global …, 2021 - Elsevier
Objectives Staphylococcus aureus is the most common causative organism of osteomyelitis
(OM). Nevertheless, the molecular epidemiology of S. aureus causing OM remains ill …

Correlation of crystal violet biofilm test results of Staphylococcus aureus clinical isolates with Raman spectroscopic read‐out

C Ebert, L Tuchscherr, N Unger… - Journal of Raman …, 2021 - Wiley Online Library
Biofilm‐related infections occur quite frequently in hospital settings and require rapid
diagnostic identification as they are recalcitrant to antibiotic therapy and make special …

Differential survival of Staphylococcal species in macrophages

J Bayer, J Becker, X Liu, L Gritsch… - Molecular …, 2024 - Wiley Online Library
Staphylococcus aureus is considered an extracellular pathogen, yet the bacterium is able to
survive within and escape from host cells. An agr/sae mutant of strain USA300 is unable to …

The crossroads between infection and bone loss

TC Oliveira, MS Gomes, AC Gomes - Microorganisms, 2020 - mdpi.com
Bone homeostasis, based on a tight balance between bone formation and bone
degradation, is affected by infection. On one hand, some invading pathogens are capable of …