3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major
pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from …

The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

Since the incidence of the metabolic syndrome is on the rise in the western world, its
coherence to cancer is becoming more apparent. In this review we discuss the different …

Phosphoinositide 3-kinases (PI3Ks) are implicated in a broad spectrum of cellular activities,
such as growth, proliferation, differentiation, migration, and metabolism. Activation of class I …

The 14-3-3 proteins were the first phosphoserine/phosphothreonine-binding proteins to be
discovered, a finding that provided the foundation for their prominent role in cell signaling …

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed
in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …

The class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that transduce a host of
cellular signals and regulate a broad range of essential functions including growth …

Transforming growth factor β (TGF-β) functions as a tumor suppressor in premalignant cells
but as a metastasis promoter in cancer cells. The dichotomous functions of TGF-β are …

Abstract YWHAZ (also named 14-3-3ζ) is a central hub protein for many signal transduction
pathways and plays a significant role in tumor progression. Accumulating evidences have …