A great deal of research aims to identify risk factors related to individual vulnerability to
develop stress-induced psychopathologies. Here, we summarize evidence that point at …

Chronic, severe irritability is common in childhood and is very impairing. Furthermore,
childhood irritability predicts suicidality, social impairment, and depressive and anxiety …

Women are more likely than men to suffer from post-traumatic stress disorder (PTSD) and
major depression. In addition to their sex bias, these disorders share stress as an etiological …

We report analyses from a study of gene–environment interaction in adolescent depression.
The sample was selected from 1990 adolescents aged 10–20 years: those with depression …

Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that
are specific to certain disorders or syndromes. The objective of this paper is to summarise …

Sex differences in the genetic epidemiology and clinical features of psychiatric disorders are
well recognized, but the individual genes contributing to these effects have rarely been …

This review examines the neural correlates of Gray's model (Gray and McNaughton, 2000;
McNaughton and Corr, 2004), supplemented by a fourth dimension: constraint (Carver …

Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth,
reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a …

Anxiety and depression share a long, close history in psychiatric nosology and treatment.
The anxiety disorders, individually and as a group, exhibit remarkably high rates of …

Various genes are known to modulate the delicate balance of dopamine in prefrontal cortex
and influence cortical information processing. Catechol-O-methyltransferase (COMT) on …