Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

J Yan, X Ma, D Liang, M Ran, D Zheng, X Chen… - Nature …, 2023 - nature.com
Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but
their ability to recognize disease tissue and further achieve synergistic gene regulation has …

Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …

A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure

S Li, T Tian, T Zhang, Y Lin, X Cai - Nature Protocols, 2024 - nature.com
As microRNAs (miRNA) regulate almost all physiopathological activities in the human body,
miRNA therapeutics that deliver miRNA regulators have attracted considerable attention in …

From molecular mechanisms to therapeutics: understanding MicroRNA-21 in cancer

J Rhim, W Baek, Y Seo, JH Kim - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …

Current achievements and applications of transcriptomics in personalized cancer medicine

S Supplitt, P Karpinski, M Sasiadek… - International Journal of …, 2021 - mdpi.com
Over the last decades, transcriptome profiling emerged as one of the most powerful
approaches in oncology, providing prognostic and predictive utility for cancer management …

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer's disease

NM Abdelmaksoud, AAM Sallam, AI Abulsoud… - … -Research and Practice, 2024 - Elsevier
Alzheimer's disease (AD) is a multifaceted, advancing neurodegenerative illness that is
responsible for most cases of neurological impairment and dementia in the aged population …

Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases

AN Saiyed, AR Vasavada, SRK Johar - Future Journal of Pharmaceutical …, 2022 - Springer
Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …