Enzymatic reactions play a fundamentally important role in controlling and performing most
life processes. 1-3 Thus, understanding how enzymes work has both fundamental and …

Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

For the investigation of chemical reaction networks, the identification of all relevant
intermediates and elementary reactions is mandatory. Many algorithmic approaches exist …

The construction of a reaction network containing all relevant intermediates and elementary
reactions is necessary for the accurate description of chemical processes. In the case of a …

Nucleic acid polymerases catalyze the formation of DNA or RNA from nucleoside-
triphosphate precursors. Amino acid residues in the active site of polymerases are thought to …

The results of a comprehensive study on the double-proton transfer in Adenine− Thymine
(AT) and Guanine− Cytosine (GC) base pairs at room temperature in gas phase and with the …

To dissect the effects of the nucleotide-binding and catalytic metal ions on DNA polymerase
mechanisms for DNA repair and synthesis, aside from the chemical reaction, we investigate …

Non-segmented negative strand (NNS) RNA viruses belonging to the order
Mononegavirales are highly diversified eukaryotic viruses including significant human …

The rate-limiting step for nucleotide incorporation in the pre-steady state for most nucleic
acid polymerases is thought to be a conformational change. As a result, very little …

Publisher Summary This chapter focuses on the progress and the current state of
structure/function correlations of biomolecules. One of the primary goals of modern …