Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

H Kaurav, M Tripathi, SD Kaur, A Bansal, DN Kapoor… - Pharmaceutics, 2024 - mdpi.com
In recent years, there has been a notable surge in the utilization of stabilized bile acid
liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery …

'Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity': in-vitro and insilico studies

MY Zakaria, SM Abd El-Halim, BY Beshay, I Zaki… - Drug Delivery, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) predisposed to the
emergence of worldwide catastrophe that impels the evolution of safe and effective …

Ultra-deformable free fatty acid based nano-carriers for topical delivery of Luteolin: A potential paradigm for management of Methicillin-Resistant Staphylococcus …

MY Zakaria, WA Eraqi, SA Mohamed - International Journal of …, 2023 - Elsevier
The incidences of antimicrobial resistance in particular, Methicillin-Resistant Staphylococcus
aureus (MRSA) have increased during the last two decades. However, conventional dosage …

Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: A repurposing approach

M Kharouba, A El-Kamel, R Mehanna, E Thabet… - Drug Delivery, 2022 - Taylor & Francis
Albeit its established efficacy as an anti-hyperlipidemic agent, pitavastatin (PIT) has been
shown to have other various therapeutic effects. One of these effects is the anti-cancer …

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and …

I Zaki, AMY Moustafa, BY Beshay… - Journal of enzyme …, 2022 - Taylor & Francis
A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4
analogues have been designed and synthesised. These compounds have been evaluated …

Employment of PEGylated ultra-deformable transferosomes for transdermal delivery of tapentadol with boosted bioavailability and analgesic activity in post-surgical …

P Deng, RE Masoud, WM Alamoudi… - International journal of …, 2022 - Elsevier
The utilization of the proper and safe analgesics was considered a major concern in pain
alleviation especially that associated with surgical procedures. Novel analgesics as …

Design, synthesis and cytotoxicity screening of new synthesized pyrimidine-5-carbonitrile derivatives showing marked apoptotic effect

I Zaki, RE Masoud, MMS Hamoud, OAA Ali… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrimidine-5-carbonitriles has been designed and synthesized as potent
anticancer agents. Pyrimidine-5-carbonitriles 2-6d have been assessed for their cytotoxic …

Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: factorial design, in-vitro and in-vivo …

MY Zakaria, I Zaki, M Alhomrani, AS Alamri… - Drug Delivery, 2022 - Taylor & Francis
Resveratrol (RSV) is a phytoceutical polyphenolic compound exhibiting a well evidenced
wide range of therapeutic activities. Unfortunately, its diminished aqueous solubility and …

Exploitation of transdermal nanobilosomal gel platforms for ameliorating anti-diabetic activity of empagliflozin following I-optimal design

TM Ibrahim - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
The current study aimed to optimize a bilosomal gel (bilo-gel) formulation loaded with anti-
diabetic empagliflozin. Enhancement of transdermal delivery of empagliflozin was targeted …

[HTML][HTML] Design, Synthesis, and Investigation of Cytotoxic Activity of cis-Vinylamide-Linked Combretastatin Analogues as Potential Anticancer Agents

T Al-Warhi, LS Alqahtani, G Alsharif, M Abualnaja… - Symmetry, 2022 - mdpi.com
The combretastatins (cis-stilbenoid molecules) have received significant interest because of
their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin …