Natural products as leads in schistosome drug discovery

BJ Neves, CH Andrade, PVL Cravo - Molecules, 2015 - mdpi.com
Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human
lives every year. Praziquantel (PZQ), the only drug recommended by the World Health …

The medicinal chemistry of genus Aralia

JA Clement, E SH Clement - Current topics in medicinal …, 2014 - ingentaconnect.com
The genus Aralia contains many plants used medicinally in Asia and the Americas. Although
many members of this genus are used medicinally, the vast majority of this genus has not …

Isolation of diterpenes from Araucaria sp Brazilian brown propolis and development of a validated high‐performance liquid chromatography method for its analysis

MFC Santos, LC Oliveira, VP Ribeiro… - Journal of …, 2021 - Wiley Online Library
Propolis comprises a complex resinous product composed of plant's parts or exudates,
pollen, bee wax, and enzymes. Brazilian brown propolis from Araucaria sp displays several …

Anthelmintic Activity of Crude Extract and Essential Oil of Tanacetum vulgare (Asteraceae) against Adult Worms of Schistosoma mansoni

LS Godinho, LS Aleixo de Carvalho… - The Scientific World …, 2014 - Wiley Online Library
Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus
Schistosoma, affects more than 200 million people worldwide, and its control is dependent …

[HTML][HTML] Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation

LC Oliveira, TS Porto, AHC Junior, MFC Santos… - Process …, 2020 - Elsevier
Schistosomiasis continues to be a huge challenge for researchers, pharmaceutical
companies, and governments in developing countries. Diterpene compounds are good …

[HTML][HTML] (±)-Licarin A and its semi-synthetic derivatives: In vitro and in silico evaluation of trypanocidal and schistosomicidal activities

VR Meleti, VR Esperandim, LGB Flauzino… - Acta tropica, 2020 - Elsevier
This paper reports the synthesis of (±)-licarin A 1, a dihydrobenzofuran neolignan, resultant
of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme …

Copaifera duckei Oleoresin and Its Main Nonvolatile Terpenes: In Vitro Schistosomicidal Properties

CHG Borges, MG Cruz, LJ Carneiro… - Chemistry & …, 2016 - Wiley Online Library
In this article, the in vitro schistosomicidal effects of three Brazilian Copaifera oleoresins (C.
duckei, C. langsdorffii, and C. reticulata) are reported. From these botanical sources, the …

Diterpenes as lead molecules against neglected tropical diseases

MVO Barros de Alencar… - Phytotherapy …, 2017 - Wiley Online Library
Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor
and developing areas in the world have received great attention to NTDs. Drug resistance …

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

GA Dziwornu, HD Attram, S Gachuhi… - RSC Medicinal …, 2020 - pubs.rsc.org
Globally, schistosomiasis threatens more than 700 million lives, mostly children, in poor
localities of tropical and sub-tropical areas with morbidity due to acute and chronic …

Anti‐Schistosoma mansoni effects of essential oils and their components

MT Islam, M Martorell, B Salehi, WN Setzer… - Phytotherapy …, 2020 - Wiley Online Library
Schistosoma mansoni is endemic in 55 countries around the world. S. mansoni is a water‐
borne parasite of humans belonging to the group of blood flukes. Generally, schistosomiasis …