Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic
structure. One of their most important properties, is that their inner cavity is hydrophobic …

The use of oral anticancer drugs has increased during the last decade, because of patient
preference, lower costs, proven efficacy, lack of infusion-related inconveniences, and the …

Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low
bioavailability because of poor aqueous solubility and low intestinal absorption. A quercetin …

The objective of this study was to examine the cellular effects of the members of two non-
ionic amphiphilic tenside groups and their mixtures on human Caco-2 cell monolayers as …

For developing a multifunctional bioreducible targeted and synergistic co-delivery system for
anticancer drug paclitaxel (PTX) and p53 gene for potential cancer therapy, supramolecular …

Chrysin is a bioflavonoid that can be found in natural products such as honey and propolis,
and it possesses several biological effects such as antioxidant, anti-inflammatory, and anti …

Biological barriers are the main defense systems of the homeostasis of the organism and
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …

Paclitaxel (PTX), a hydrophobic anticancer drug, is facing several clinical limitations such as
low bioavailability and drug resistance. To solve the problems, a well-defined β-cyclodextrin …

The solubility-permeability interplay deals with the question: what is the concomitant effect
on the drug's apparent permeability when increasing the apparent solubility with a solubility …

Oral delivery of therapeutics is extremely challenging. The digestive system is designed in a
way that naturally allows the degradation of proteins or peptides into small molecules prior …