Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …