The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play
important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is …

Paneth cells were first described in the late 19th century by Gustav Schwalbe and Josef
Paneth as columnar epithelial cells possessing prominent eosinophilic granules in their …

Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

The gut epithelium has remarkable self-renewal capacity that under homeostatic conditions
is driven by Wnt signalling in Lgr5+ intestinal stem cells (ISCs). However, the mechanisms …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Recent examples have highlighted how stem cells have the capability to initiate
morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel …

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …

The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

Paneth cells are post-mitotic intestinal epithelial cells supporting the stem cell niche and
mucosal immunity. Paneth cell pathologies are observed in various gastrointestinal …