The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Biology and therapeutic potential of interleukin-10

M Saraiva, P Vieira, A O'garra - Journal of Experimental Medicine, 2019 - rupress.org
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Differential roles of M1 and M2 microglia in neurodegenerative diseases

Y Tang, W Le - Molecular neurobiology, 2016 - Springer
One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …

Macrophages: development and tissue specialization

C Varol, A Mildner, S Jung - Annual review of immunology, 2015 - annualreviews.org
Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

The paradoxical role of IL-10 in immunity and cancer

MH Mannino, Z Zhu, H Xiao, Q Bai, MR Wakefield… - Cancer letters, 2015 - Elsevier
Abstract Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic
cytokine. It has been implicated in the pathogenesis and/or development of autoimmune …

The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Interleukin-10 prevents pathological microglia hyperactivation following peripheral endotoxin challenge

A Shemer, I Scheyltjens, GR Frumer, JS Kim… - Immunity, 2020 - cell.com
Microglia, the resident macrophages of the brain parenchyma, are key players in central
nervous system (CNS) development, homeostasis, and disorders. Distinct brain pathologies …

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

E Zigmond, B Bernshtein, G Friedlander, CR Walker… - Immunity, 2014 - cell.com
Summary Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and
sensed by most hematopoietic cells. Genome-wide association studies and experimental …

[HTML][HTML] Nonresolving inflammation

C Nathan, A Ding - Cell, 2010 - cell.com
Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an
inherent risk because inflammation can damage tissue and necrosis can provoke …