Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level

JT Hespanhol, L Nóbrega-Silva… - …, 2023 - microbiologyresearch.org
Bacteria live in complex polymicrobial communities and are constantly competing for
resources. The type VI secretion system (T6SS) is a widespread antagonistic mechanism …

The type-VI secretion system of the beneficial symbiont Vibrio fischeri

KR Guckes, TI Miyashiro - Microbiology, 2023 - microbiologyresearch.org
The mutualistic symbiosis between the Hawaiian bobtail squid Euprymna scolopes and the
marine bacterium Vibrio fischeri is a powerful experimental system for determining how …

Calcium promotes T6SS-mediated killing and aggregation between competing symbionts

L Speare, A Jackson, AN Septer - Microbiology Spectrum, 2022 - Am Soc Microbiol
Bacteria use a variety of strategies to exclude competitors from accessing resources,
including space within a host niche. Because these mechanisms are typically costly to …

Comparative phenotype and transcriptome analysis revealed the role of ferric uptake regulator (Fur) in the virulence of Vibrio harveyi isolated from diseased American …

Q Wan, S Zhai, M Chen, M Xu… - Journal of Fish Diseases, 2024 - Wiley Online Library
Vibrio harveyi is commonly found in salt and brackish water and is recognized as a serious
bacterial pathogen in aquaculture worldwide. In this study, we cloned the ferric uptake …

Prevalence and diversity of type VI secretion systems in a model beneficial symbiosis

AM Suria, S Smith, L Speare, Y Chen, I Chien… - Frontiers in …, 2022 - frontiersin.org
The type VI secretion system (T6SS) is widely distributed in diverse bacterial species and
habitats where it is required for interbacterial competition and interactions with eukaryotic …

Quorum sensing inhibits interference competition among bacterial symbionts within a host

KR Guckes, TA Yount, CH Steingard, TI Miyashiro - Current Biology, 2023 - cell.com
The symbioses that animals form with bacteria play important roles in health and disease,
but the molecular details underlying how bacterial symbionts initially assemble within a host …

[HTML][HTML] The Vibrio fischeri type VI secretion system incurs a fitness cost under host-like conditions

AN Septer, G Sharpe, EA Shook - bioRxiv, 2023 - ncbi.nlm.nih.gov
The type VI secretion system (T6SS) is an interbacterial weapon composed of thousands of
protein subunits and predicted to require significant cellular energy to deploy, yet a fitness …

A prototrophic suppressor of a Vibrio fischeri D-glutamate auxotroph reveals a member of the periplasmic broad-spectrum racemase family (BsrF)

MN Coppinger, K Laramore, DL Popham… - Journal of …, 2024 - Am Soc Microbiol
Although bacterial peptidoglycan (PG) is highly conserved, some natural variations in PG
biosynthesis and structure have evolved. Understanding the mechanisms and limits of such …

[HTML][HTML] Flagella are required to coordinately activate competition and host colonization factors in response to a mechanical signal

L Speare, L Zhao, MN Pavelsky, A Jackson, S Smith… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Bacteria employ antagonistic strategies to eliminate competitors of an ecological niche.
Contact-dependent mechanisms, such as the type VI secretion system (T6SS), are prevalent …

A subcellular biochemical model for T6SS dynamics reveals winning competitive strategies

YL Lin, SN Smith, E Kanso, AN Septer… - PNAS nexus, 2023 - academic.oup.com
The type VI secretion system (T6SS) is a broadly distributed interbacterial weapon that can
be used to eliminate competing bacterial populations. Although unarmed target populations …