This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

The term phenotype in the field of COPD is defined as “a single or combination of disease
attributes that describe differences between individuals with COPD as they relate to clinically …

The coronavirus disease 2019 (COVID-19), is a highly contagious transmittable disease
caused by a recently discovered coronavirus, pathogenic SARS-CoV-2. Followed by the …

Genetic variation contributes to host responses and outcomes following infection by
influenza A virus or other viral infections. Yet narrow windows of disease symptoms and …

Phylogenetically conserved serine protease cascades play an important role in invertebrate
and vertebrate immunity. The mammalian coagulation system can be traced back some 400 …

Mannose-binding lectin (MBL) is a serum protein that plays an important role in host
defenses as an opsonin and through activation of the complement system. The objective of …

Ficolins are a family of oligomeric proteins consisting of an N-terminal collagen-like domain
and a C-terminal globular fibrinogen-like domain. They are novel lectins that employ the …

Lung diseases are among the leading causes of morbidity and mortality. Complement
activation may prevent a variety of respiratory infections, but on the other hand, could …

Background Mannose-binding lectin (MBL) is a key component of innate immunity. MBL
deficiency is common (10–30% of the general population depending on the definition used) …