Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …

The extracellular matrix (ECM) determines functional properties of connective tissues
through structural components, such as collagens, elastic fibers, or proteoglycans. The ECM …

Aims Heart failure is a condition with high mortality rates, and there is a lack of therapies that
directly target maladaptive changes in the extracellular matrix (ECM), such as fibrosis. We …

Myogenesis is the process that generates multinucleated contractile myofibers from muscle
stem cells during skeletal muscle development and regeneration. Myogenesis is governed …

Heart failure is a major cause of morbidity and mortality worldwide, and can result from
pressure overload, where cardiac remodelling is characterized by cardiomyocyte …

Aims Transforming growth factor (TGF)-β is up-regulated in the diabetic myocardium and
may mediate fibroblast activation. We aimed at examining the role of TGF-β-induced …

The ADAMTS superfamily is composed of secreted metalloproteases and structurally related
non-catalytic ADAMTS-like proteins. A subset of this superfamily, including ADAMTS6 …

Fibrous dysplasia (FD) is a rare bone disorder characterized by the replacement of normal
bone with benign fibro-osseous tissue. Developments in our understanding of the …

Abstract Geleophysic dysplasia-1 (GD1) is an autosomal recessive disorder caused by
ADAMTS-like 2 (ADAMTSL2) variants. It is characterized by distinctive facial features, limited …

Autoimmune Encephalitis (AE) spans a group of non-infectious inflammatory conditions of
the central nervous system due to an imbalanced immune response. Aiming to elucidate the …