Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Purpose The aims of the TP53 Colorectal Cancer (CRC) International Collaborative Study
were to evaluate the possible associations between specific TP53 mutations and tumor site …

We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in
the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic …

Appropriate subcellular localization is crucial for regulating p53 function. We show that p53
export is mediated by a highly conserved leucine-rich nuclear export signal (NES) located in …

Nuclear localization of p53 is essential for its tumor suppressor function. Here, we have
identified Parc, a Parkin-like ubiquitin ligase, as a cytoplasmic anchor protein in p53 …

The regulation of p53 functions is tightly controlled through several mechanisms including
p53 transcription and translation, protein stability, post-translational modifications, and …

Colorectal cancer is a significant cause of morbidity and mortality in Western populations.
This cancer develops as a result of the pathologic transformation of normal colonic …

Despite intensive study of p53, the regulation of p53 cellular localization is still poorly
understood. This is an overview of the elements and molecules involved in p53 …

Angiogenesis is a crucial step in tumor growth and progression. Its quantitation by
microvessel counting is of prognostic value in several types of malignancies. Scarce data …

It has been four decades since the discovery of p53, the designated 'Guardian of the
Genome'. P53 is primarily known as a master transcription factor and critical tumor …