Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques
Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
Discovery of NSD2 non-histone substrates and design of a super-substrate
The human protein lysine methyltransferase NSD2 catalyzes dimethylation at H3K36. It has
very important roles in development and disease but many mechanistic features and its full …
very important roles in development and disease but many mechanistic features and its full …
Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues
The HEMK2 protein methyltransferase has been described as glutamine methyltransferase
catalyzing ERF1‐Q185me1 and lysine methyltransferase catalyzing H4K12me1. Methylation …
catalyzing ERF1‐Q185me1 and lysine methyltransferase catalyzing H4K12me1. Methylation …
Molecular dynamics simulations of the substrate-and product specificity and mechanism of DNA-and protein lysine methyltransferases
P Schnee - 2024 - elib.uni-stuttgart.de
Protein Lysine Methyltransferases (PKMTs) regulate the epigenetic code of cells and their
alteration via somatic mutations are often associated with cancer. The aim of this project is to …
alteration via somatic mutations are often associated with cancer. The aim of this project is to …