Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Targeting DNA repair in cancer: beyond PARP inhibitors
JS Brown, B O'Carrigan, SP Jackson, TA Yap - Cancer discovery, 2017 - AACR
Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …
understanding of its genomic impact is limited. We analyzed mutational spectra following …
Harnessing DNA double-strand break repair for cancer treatment
A Trenner, AA Sartori - Frontiers in oncology, 2019 - frontiersin.org
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
DNA-PKcs: a multi-faceted player in DNA damage response
X Yue, C Bai, D Xie, T Ma, PK Zhou - Frontiers in genetics, 2020 - frontiersin.org
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
Pathways and mechanisms of venetoclax resistance
P Bose, V Gandhi, M Konopleva - Leukemia & lymphoma, 2017 - Taylor & Francis
The approval of venetoclax, a 'BH3-mimetic'antagonist of the BCL-2 anti-apoptotic protein,
for chronic lymphocytic leukemia represents a major milestone in translational apoptosis …
for chronic lymphocytic leukemia represents a major milestone in translational apoptosis …
Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells
Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …
The role of the core non-homologous end joining factors in carcinogenesis and cancer
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice
Glioblastoma (GBM), a lethal primary brain tumor, contains glioma stem cells (GSCs) that
promote malignant progression and therapeutic resistance. SOX2 is a core transcription …
promote malignant progression and therapeutic resistance. SOX2 is a core transcription …
Therapeutic targeting of DNA damage response in cancer
W Choi, ES Lee - International journal of molecular sciences, 2022 - mdpi.com
DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …
signaling pathway are highly associated with carcinogenesis and tumor progression …