The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …

Background: Insulin-like growth factor 2 (IGF2) is a protein hormone known to regulate cell
proliferation, growth, migration, differentiation and survival. The gene is parentally imprinted …

Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the
development of various diseases, including heart failure. However, the molecular …

The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling
through an intricate network of related receptors and hormones. IGF-II is one of several …

Objective Although the quest for longevity is as old as civilization itself, only recently have
technical and conceptual advances in genomics research brought us to the point of …

Cardiovascular diseases are the leading cause of death around the world and the insulin-
like growth factor (IGF)-system has multiple functions for the pathological conditions of …

Determination of the prognosis and treatment outcomes of dilated cardiomyopathy is a
serious problem due to the lack of valid specific protein markers. Using in-depth proteome …

There is a growing body of literature focusing on the somatotropic axis and regulation of
aging and longevity. Many of these reports derive data from multiple endocrine mutants …

Background Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a
devastating cerebrovascular disorder, which could benefit from collateral circulation …

Abstract The IGF2–INS–TH genomic region has been implicated in various common
disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease …