Radiation-induced lung fibrosis (RILF) is a severe side effect of radiotherapy in lung cancer
patients that presents as a progressive pulmonary injury combined with chronic …

Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic
radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a …

Aims The cell adhesion molecules (CAMs) that mediate neutrophil-endothelium cell
adhesion are deeply involved in the pathogenesis of acute lung injury (ALI). B-cell receptor …

Chronic injury often triggers maladaptive wound healing responses leading to the
development of tissue fibrosis and subsequent organ malfunction. Inflammation is a key …

Extracellular adenosine is a potent endogenous immunosuppressive mediator critical to the
maintenance of homeostasis in various normal tissues including the lung. Adenosine is …

Radiation-induced pneumonitis and fibrosis are dose-limiting side effects of thoracic
irradiation. Thoracic irradiation triggers acute and chronic environmental lung changes that …

Radiation-induced pulmonary fibrosis (RIPF) is a common complication in patients with lung
cancer and breast cancer after receiving thoracic radiotherapy. The average incidence of …

Organisms respond to physical, chemical and biological threats by a potent inflammatory
response, aimed at preserving tissue integrity and restoring tissue homeostasis and …

Recent strategies to combine chemoradiation with immunotherapy to treat locally advanced
lung cancer have improved five-year survival outcomes. However, collateral toxicity to …