Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

During genome replication, parental histones are recycled to newly replicated DNA with
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …

The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Although DNA replication is a fundamental aspect of biology, it is not known what
determines where DNA replication starts and stops in the human genome. We directly …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …

In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication
named origins are dispersed across each of the linear chromosomes. During S-phase, only …

As transcription and replication use DNA as substrate, conflicts between transcription and
replication can occur, leading to genome instability with direct consequences for human …