Photothermal microscopy: imaging the optical absorption of single nanoparticles and single molecules

S Adhikari, P Spaeth, A Kar, MD Baaske, S Khatua… - ACS …, 2020 - ACS Publications
The photothermal (PT) signal arises from slight changes of the index of refraction in a
sample due to absorption of a heating light beam. Refractive index changes are measured …

Multimodal nonlinear optical microscopy

S Yue, MN Slipchenko, JX Cheng - Laser & photonics reviews, 2011 - Wiley Online Library
Because each nonlinear optical (NLO) imaging modality is sensitive to specific molecules or
structures, multimodal NLO imaging capitalizes the potential of NLO microscopy for studies …

Overtone photothermal microscopy for high-resolution and high-sensitivity vibrational imaging

L Wang, H Lin, Y Zhu, X Ge, M Li, J Liu, F Chen… - Nature …, 2024 - nature.com
Photothermal microscopy is a highly sensitive pump-probe method for mapping
nanostructures and molecules through the detection of local thermal gradients. While visible …

Determination of carcinoembryonic antigen in human sera by integrated bead-bed immunoasay in a microchip for cancer diagnosis

K Sato, M Tokeshi, H Kimura, T Kitamori - Analytical Chemistry, 2001 - ACS Publications
A bead-bed immunoassay system was structured on a microchip and applied to determine
carcinoembryonic antigen (CEA), which is a commonly used marker of colon cancer …

Determination of subyoctomole amounts of nonfluorescent molecules using a thermal lens microscope: subsingle-molecule determination

M Tokeshi, M Uchida, A Hibara, T Sawada… - Analytical …, 2001 - ACS Publications
The photothermal effect of an ultratrace amount of nonfluorescent molecules in liquid was
determined by optimizing the optical arrangement for a thermal lens microscope. The …

Ground-state depletion microscopy: detection sensitivity of single-molecule optical absorption at room temperature

S Chong, W Min, XS Xie - The journal of physical chemistry letters, 2010 - ACS Publications
Optical studies of single molecules in ambient environments, which have led to broad
applications, are primarily based on fluorescence detection. Direct detection of optical …

The use of microfluidic devices in solvent extraction

D Ciceri, JM Perera, GW Stevens - Journal of Chemical …, 2014 - Wiley Online Library
Solvent extraction (SX) is an important separation method with countless applications in the
chemical industry. The water/oil interface is an essential feature of SX systems. Microfluidic …

[PDF][PDF] Peer reviewed: thermal lens microscopy and microchip chemistry

T Kitamori, M Tokeshi, A Hibara, K Sato - 2004 - ACS Publications
Thermal Lens Microscopy and Microchip Chemistry Page 1 Thermal Lens Microscopy and
Microchip Chemistry Page 2 hermal lens microscopy (TLM) is very sensitive to nonluminescent …

Microchip‐based immunoassay system with branching multichannels for simultaneous determination of interferon‐γ

K Sato, M Yamanaka, H Takahashi, M Tokeshi… - …, 2002 - Wiley Online Library
A bead‐bed immunoassay system suitable for simultaneous assay of multiple samples was
constructed on a microchip. The chip had branching multichannels and four reaction and …

Microchip-based chemical and biochemical analysis systems

K Sato, A Hibara, M Tokeshi, H Hisamoto… - Advanced drug delivery …, 2003 - Elsevier
This review focuses on chemical and biochemical analysis systems using pressure-driven
microfluidic devices or microchips. Liquid microspace in a microchip has several …