[HTML][HTML] Cyanobacterial peptides beyond microcystins–A review on co-occurrence, toxicity, and challenges for risk assessment

EML Janssen - Water Research, 2019 - Elsevier
Cyanobacterial bloom events that produce natural toxins occur in freshwaters across the
globe, yet the potential risk of many cyanobacterial metabolites remains mostly unknown …

Stereoselective halogenation in natural product synthesis

W Chung, CD Vanderwal - Angewandte Chemie International …, 2016 - Wiley Online Library
At last count, nearly 5000 halogenated natural products have been discovered. In
approximately half of these compounds, the carbon atom to which the halogen is bound is …

Marine natural products

JW Blunt, BR Copp, WP Hu, MHG Munro… - Natural product …, 2008 - pubs.rsc.org
Covering: 2006. Previous review: Nat. Prod. Rep., 2007, 24, 31 This review covers the
literature published in 2006 for marine natural products, with 758 citations (534 for the …

Cutting-edge and time-honored strategies for stereoselective construction of C–N bonds in total synthesis

AK Mailyan, JA Eickhoff, AS Minakova, Z Gu… - Chemical …, 2016 - ACS Publications
The main objective of this review is to provide a comprehensive survey of methods used for
stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen …

Recent advances in the chemistry and biology of naturally occurring antibiotics

KC Nicolaou, JS Chen, DJ Edmonds… - Angewandte Chemie …, 2009 - Wiley Online Library
Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

Chemistry and biology of the aeruginosin family of serine protease inhibitors

K Ersmark, JR Del Valle… - Angewandte Chemie …, 2008 - Wiley Online Library
The aeruginosins have been isolated from marine sponges and cyanobacterial
waterblooms, sources that are phylogenetically distinct and the bodies of water are …

Chemodiversity in freshwater and terrestrial cyanobacteria-a source for drug discovery

GE Chlipala, S Mo, J Orjala - Current drug targets, 2011 - ingentaconnect.com
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds
and a large number of chemically diverse and bioactive metabolites have been obtained …

Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria

PM D'Agostino - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to 2023 Cyanobacteria have long been known for their intriguing repertoire of
natural product scaffolds, which are often distinct from other phyla. Cyanobacteria are …

The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids

S Hanessian, L Auzzas - Accounts of chemical research, 2008 - ACS Publications
Medicinal chemistry has witnessed major advances with the discovery of small synthetic
molecules that mimic natural peptidic substrates. These small synthetic mimics do not …

Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom

D Filatova, MR Jones, JA Haley, O Núñez… - Environmental Sciences …, 2021 - Springer
Background Bloom-forming cyanobacteria occur globally in aquatic environments. They
produce diverse bioactive metabolites, some of which are known to be toxic. The most …