Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Objectives This longitudinal study compared emerging plasma biomarkers for
neurodegenerative disease between controls, patients with Alzheimer's disease (AD), Lewy …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes …

Neuroinflammation plays a major role in the etiopathology of neurodegenerative diseases,
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …

The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since
2020. Links between the newly discovered viral infection and the pathogenesis of …

Abstract β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN)
are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks …

Parkinson's disease (PD) is conventionally described as an α-synuclein aggregation
disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase …

Background The genetic basis of variation in the progression of primary tauopathies has not
been determined. We aimed to identify genetic determinants of survival in progressive …