Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and
lenalidomide are the most common cereblon (CRBN) recruiters in proteolysis-targeting …

Accumulation of misfolded proteins challenges cellular proteostasis and is implicated in
aging and chronic disorders. Cancer cells, moreover, face an elevated level of basal …

Few chemistries are suitable for in-cell protein labeling, and the required reagents are
costly. We present an approach for the coupled biosynthesis and genetic encoding of …

The synthesis of caged luminescent peptide substrates remains challenging, especially
when libraries of the substrates are required. Most currently available synthetic methods rely …

Bioorthogonal reactions hold significant promise for applications in chemical biology.
Despite their potential, nitriles have often been overlooked as reactive functional groups for …

Inspired by the chemical reactivity of apalutamide, we have developed an efficient method
for N-terminal cysteine bioconjugation with 2-cyanopyridine derivatives. Systematic …

Sažetak In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs)
catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β …

Teredinibactins are ß-resorcyclic thiazoline dipeptides synthesized by Teredinibacter
turnerae T7901, a bacterial symbiont of shipworms in the sea. Through feeding studies, we …