In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …

Ornithine δ-aminotransferase (OAT, EC 2.6. 1.13) catalyzes the transfer of the δ-amino
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …

Background Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by
diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone …

Disrupted sleep is a major feature of Alzheimer's disease (AD), often arising years before
symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of …

Na+-H+ exchanger regulatory factor-1 (NHERF1) is a PDZ protein that scaffolds membrane
proteins, including sodium–phosphate co-transport protein 2A (NPT2A) at the plasma …

Abstract Background Obesity is heritable. It predisposes to many diseases. The objectives of
this study were to create a compendium of genes relevant to feeding behavior (FB) and/or …

Mechanisms that prevent aggregation and promote folding of nascent G protein–coupled
receptors (GPCRs) remain poorly understood. We identified chaperonin containing TCP-1 …

Keratin 9 was recently identified as an important component of a biomarker panel which
demonstrated a high diagnostic accuracy (87%) for Alzheimer's disease (AD) …

Background Mechanisms governing localization, trafficking and signaling of G protein-
coupled receptors (GPCRs) are critical in cell function. Protein-protein interactions are …

The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) mediates
essential functions in several cell types and is implicated in cardiovascular pathologies, skin …