[HTML][HTML] Organotypic brain slice cultures: A review
C Humpel - Neuroscience, 2015 - Elsevier
In vitro cell cultures are an important tool for obtaining insights into cellular processes in an
isolated system and a supplement to in vivo animal experiments. While primary dissociated …
isolated system and a supplement to in vivo animal experiments. While primary dissociated …
Crosstalk between poly (ADP-ribose) polymerase and sirtuin enzymes
Abstract Poly (ADP-ribose) polymerases (PARPs) are NAD+ dependent enzymes that were
identified as DNA repair proteins, however, today it seems clear that PARPs are responsible …
identified as DNA repair proteins, however, today it seems clear that PARPs are responsible …
Structural basis for potency and promiscuity in poly (ADP-ribose) polymerase (PARP) and tankyrase inhibitors
AG Thorsell, T Ekblad, T Karlberg… - Journal of medicinal …, 2017 - ACS Publications
Selective inhibitors could help unveil the mechanisms by which inhibition of poly (ADP-
ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 …
ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 …
Dysregulated metabolic pathways in age-related macular degeneration
Age-related macular degeneration is a major cause of vision impairment in the Western
world among people of 55 years and older. Recently we have shown that autophagy is …
world among people of 55 years and older. Recently we have shown that autophagy is …
Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function
Androgen receptor (AR) is a ligand-activated transcription factor and a key driver of prostate
cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated …
cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated …
Target engagement imaging of PARP inhibitors in small-cell lung cancer
Insufficient chemotherapy response and rapid disease progression remain concerns for
small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment …
small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment …
PARP-1 inhibition is neuroprotective in the R6/2 mouse model of Huntington's disease
A Cardinale, E Paldino, C Giampà, G Bernardi… - PloS one, 2015 - journals.plos.org
Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that is involved in
physiological processes as DNA repair, genomic stability, and apoptosis. Moreover …
physiological processes as DNA repair, genomic stability, and apoptosis. Moreover …
Central nervous system agents for ischemic stroke: neuroprotection mechanisms
RS Pandya, L Mao, H Zhou, S Zhou… - … System Agents in …, 2011 - ingentaconnect.com
Stroke is the third leading cause of mortality and disability in the United States. Ischemic
stroke constitutes 85% of all stroke cases. However, no effective treatment has been found to …
stroke constitutes 85% of all stroke cases. However, no effective treatment has been found to …
PARP inhibitors: new tools to protect from inflammation
V Giansanti, F Donà, M Tillhon, AI Scovassi - Biochemical pharmacology, 2010 - Elsevier
Poly (ADP-ribosylation) consists in the conversion of β-NAD+ into ADP-ribose, which is then
bound to acceptor proteins and further used to form polymers of variable length and …
bound to acceptor proteins and further used to form polymers of variable length and …
PARP inhibitors: polypharmacology versus selective inhibition
T Ekblad, E Camaioni, H Schüler… - The FEBS …, 2013 - Wiley Online Library
Inhibition of ADP‐ribosyltransferases with diphtheria toxin homology (ARTD), widely known
as the poly (ADP‐ribose) polymerase (PARP) family, is a strategy under development for …
as the poly (ADP‐ribose) polymerase (PARP) family, is a strategy under development for …